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System Biosciences

System Biosciences, Inc

SBI focuses on developing unique, innovative technologies that provide researchers with the tools to investigate and understand genomic and proteomic function. SBI's mission is to provide tools for the genome-wide analysis of the mechanisms that regulate cellular processes and biological responses.

CRISPR/Cas9 Genome Engineering

CRISPR/Cas9
  • All-in-one Cas9/gRNA plasmids
  • Injection-ready Cas9 mRNA
  • Packaged Cas9 lentivirus
  • AAV-Cas9 vectors
  • Multiplex gRNA cloning kits

The CRISPR/Cas9 system, consisting of a nuclease (Cas9) and a DNA-directed guide RNA (gRNA), allows for sequence-specific cleavage of target sequence containing a protospacer adaptor motif “NGG”. By changing the gRNA target sequence, virtually any gene sequence upstream of a PAM motif can be targeted by the CRISPR/Cas9 system, enabling the possibility of systematic targeting of sequences on a genomic scale.

Selection Guide

MODIFYING ORGANISMS
MODIFYING CELL LINES
PRE-CLINICAL APPLICATIONS
SIMULTANEOUS ENGINEERING
OF MULTIPLE MUTATIONS
ACCESSORIES

Exosome Tool Box

System Biosciences offers a full spectrum of tools and services for exosome research:

  • Exosome Isolation
  • Exosome Detection
  • Exosome Quantitation
  • Exosome Engineering
  • Biomarker Discovery
  • NGS, MS and Lipidomics Services

Lentiviral Reagents

SBI's lentiviral technology allows for efficient delivery & stable expression in most mammalian cell types:

  • Lentiviral vectors & reagents for lentivirus production and transduction
  • PEG-it solution for freezing pseudoviral particles without titer loss
  • Lentiviral Cas9 nuclease and nickase expression vectors
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