RSL3
| Specifications | |
|---|---|
| CAS Number: | 1219810-16-8 |
| Synonyms: | 1S,3R-RSL3; RSL3 1S |
| Formula: | C23H21ClN2O5 |
| Molecular Weight: | 440.88 |
| Purity: | 99.96% |
Description
RSL3 is a VDAC-independent ferroptosis activator with selectivity for tumor cells bearing oncogenic RAS. RSL3 is the inhibitor of the glutathione peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system xc- that blocks GSH synthesis (IC50: 100 nM).
