Exosome Isolation

Accelerate exosome isolation with products that enable fast, multiplexed exosome enrichment and purification from a wide range of biofluids

Get access to a comprehensive portfolio including SBI’s best-selling product ExoQuick for polymer precipitation, SmartSec for size exclusion chromatography and purification kits based on Norgen Biotek’s silicon carbide (SiC) technology.

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Visit BioCat’s Exosome Isolation Hub for a clear overview of all relevant information about exosome isolation methods.

ExoQuick Exosome Isolation

Fast and Simple Workflow
High Yield and Purity
Low Sample Input
Broad Compatibility
Preservation of Sample Integrity

The ExoQuick product family from System Biosciences enables fast, scalable, and ultracentrifugation-free isolation of exosomes and extracellular vesicles from a variety of biofluids and tissue culture media. It delivers high yields and purity even from small sample volumes.

Specialized variants address specific needs such as enhanced purity for sensitive downstream applications and compatibility with diverse sample types.

The products are widely used for biomarker discovery, RNA/protein profiling, and functional studies in both clinical and research settings.

Choose the right ExoQuick for your application

Purest EV isolation: ExoQuick ULTRA and ExoQuick-TC ULTRA - SBI's most advanced EV isolation system to date
General purpose isolation: ExoQuick (for plasma, serum, and ascites fluid) and ExoQuick-TC (for tissue culture media)
Isolate EVs from plasma or serum and remove contaminating lipoprotein particles: ExoQuick-LP
Get superior yield AND pure, ApoB-free/Albumin-reduced exosomes with the ExoQuick UltraPure EV Isolation Kit

For isolation of exosomes from cultured cells, use Exo-FBS, exosome-depleted FBS media supplement, to avoid contaminating your preps with bovine exosomes.

SmartSec Extracellular Vesicle (EV) Isolation

Cleaner Preparations
Higher EV Concentration
Fast and Easy Workflow
Broad Compatibility
Preservation of EV Integrity

SmartSEC is a size exclusion chromatography (SEC)-based technology for isolating extracellular vesicles (EVs) that combines high purity, yield, and reproducibility with a proprietary contaminant trapping feature, resulting in cleaner and more concentrated EV preparations than traditional ultracentrifugation or conventional SEC kits.

The workflow is fast and easy, validated for use with human serum, plasma, cerebrospinal fluid, and other biofluids, and is compatible with most downstream applications such as mass spectrometry, western blotting, nanoparticle tracking analysis, TEM, and RNA-sequencing.

SmartSEC delivers higher EV concentrations per fraction and lower protein contamination compared to competitor kits, making it ideal for sensitive EV research and biomarker discovery.

High Purity and Yield: SmartSEC delivers higher purity and yield of EVs compared to ultracentrifugation and conventional size exclusion chromatography (SEC) kits, thanks to its proprietary contaminant trapping technology .

Browse all SmartSEC products

Silicon-Carbide-based Purification

Norgen's Exosome Purification Kits offer a quick, dependable, and efficient way to purify and concentrate pure, intact extracellular vesicles (EVs) from various biofluids and volumes. The EVs are ready for any downstream application.

The purification is based on Norgen's proprietary resin. The kits have several advantages over other available methods. They do not require special instrumentation, ultracentrifugation, precipitation reagents, or protease treatments. More importantly, the purified exosomes will not be contaminated by other RNA-binding proteins, which could otherwise contaminate your exosomal RNA. This is essential when studying exosomal RNA gene expression.

Additional Exosome Isolation Products

In addition to the ExoQuick Precipitation Solutions, BioCat offers several more exosome isolation & purification reagents and kits from other partner companies. Browse the complete portfolio or select a Product Category or Sample Type of interest in the search engine above.