Serpina1 Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human, Mouse, Rat |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1 mg/mL |
| Buffer: | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | A1A, A1AT, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 antitrypsin null, Alpha 1 protease inhibitor, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, alpha1 proteinase inhibitor, Alpha1AT, Dom1, PI, PI1, PRO2275, Serine (or cysteine) proteinase inhibitor clade A member 1, Serine protease inhibitor 1-1, Serine protease inhibitor A1a, Serpin A1, Serpin A1a, Serpin peptidase inhibitor clade A member 1, Serpina1, Short peptide from AAT, SPAAT, Spi1-1 |
| UniProt ID: | P17475 |
Applications
WB
Recommended Dilution
WB 1:500-1000
Immunogen
Recombinant Rat Serpina1 protein expressed by E.coli
Purification/Format
Antigen Affinity Purification
Background
SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT),which is a serine protease inhibitor whose targets include elastase,plasmin,thrombin,trypsin,chymotrypsin,and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes,with smaller amountssynthesized by intestinal epithelial cells,neutrophils,pulmonary alveolar cells and macrophages. AAT is the most abundant,endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation,fibrinolysis,complement activation,apoptosis,reproduction,tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
Price
217,00 €
