Rabbit anti-GSK3 alpha/beta Polyclonal Antibody

WB, IHC-p, ELISA

WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000

Synthesized peptide derived from human GSK3α/β around the non-phosphorylation site of Tyr279/216.

Affinity purification

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3βGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.