POMC Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human, Mouse, Rat |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 0.2 mg/mL |
| Buffer: | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | ACTH, Adrenocorticotropic hormone, Adrenocorticotropin, Alpha melanocyte stimulating hormone, alpha-MSH, alphaMSH, Beta LPH, Beta melanocyte stimulating hormone, Beta-endorphin, beta-MSH, CLIP, Corticotropin, Corticotropin lipotropin, Corticotropin-like intermediary peptide, Gamma LPH, gamma-MSH, Lipotropin beta, Lipotropin gamma, Lipotropin, included, LPH, Melanocyte-stimulating hormone, included, Melanotropin alpha, Melanotropin beta, Melanotropin gamma, Melanotropin, included, Met-enkephalin, MSH, NPP, Opiomelanocortin prepropeptide, POC, POMC, Pomc-1, Pomc1, Pomc2, Pro ACTH endorphin, Pro opiomelanocortin, Pro-opiomelanocortin-alpha, Proopiomelanocortin, Proopiomelanocortin preproprotein, Tetracosactide |
| Accn. No.: | NP_000930 |
| UniProt ID: | P01189 |
Applications
WB
Recommended Dilution
WB 1:500-1:2000
Immunogen
Synthetic peptide of human POMC
Purification/Format
Affinity purification
Background
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
- Catalog Number
E-AB-15786-60ul-ELS - Supplier
Elabscience - Size
- Shipping
Blue Ice
Price
263,00 €
