PACS1 Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1mg/mL |
| Buffer: | PBS with 0.01% thiomersal,50% glycerol,pH7.3. |
| Additional Information | |
|---|---|
| Synonyms: | PACS1, MRD17, SHMS |
| UniProt ID: | Q6VY07 |
Applications
WB
Recommended Dilution
WB 1:1000-1:3000
Immunogen
Recombinant fusion protein of human PACS1
Purification/Format
Affinity purification
Background
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
Price
313,00 €
