NIPBL Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human, Mouse |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 0.9 mg/mL |
| Buffer: | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | CDLS, Colon tumor susceptibility 2, Delangin, DKFZp434L1319, FLJ11203, FLJ12597, FLJ13354, FLJ13648, FLJ44854, IDN 3, IDN 3 protein, IDN 3 protein isoform A, IDN 3 protein isoform B, IDN 3B, IDN3 B, IDN3 protein, IDN3 protein isoform A, IDN3 protein isoform B, IDN3B, Mis 4, Mis4, Nipbl, NIPBL, Nipped B homolog (Drosophila), Nipped B homolog, Nipped B like, Nipped B like protein, Nipped-B-like protein, Scc 2, SCC 2 homolog, Scc2, SCC2 homolog, Sister chromatid cohesion protein Mis4 |
| Accn. No.: | BC033847 |
| UniProt ID: | Q6KC79 |
Applications
IHC
Recommended Dilution
IHC 1:50-1:200
Immunogen
Fusion protein of human NIPBL
Purification/Format
Antigen affinity purification
Background
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.
- Catalog Number
E-AB-18915-20ul-ELS - Supplier
Elabscience - Size
- Shipping
Blue Ice
Price
202,00 €
