N-Desethyl Sunitinib hydrochloride

N-Desethyl Sunitinib (SU-12662) (hydrochloride), a metabolite of sunitinib, is a robust ATP-competitive inhibitor of VEGFR, PDGFRβ, and KIT, demonstrating inhibition constants (K i values) of 2, 9, 17, 8, and 4 nM for VEGFR-1, -2, -3, PDGFRβ, and KIT, respectively [1].