MS2177
| Specifications | |
|---|---|
| Synonyms: | MS-2177, MS 2177 |
| Formula: | C24H38N6O2 |
| Molecular Weight: | 442,61 |
Description
MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2177 to SETD8 was confirmed by isothermal titration calorimetry (ITC), having a KD of 1.3 μM.
- Price
- Please inquire
