Mouse anti-Catenin beta Monoclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Host: | Mouse |
| Reactivity: | Human, Mouse, Rat |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1 mg/mL |
| Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Additional Information | |
|---|---|
| Synonyms: | Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein), beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289 |
| Gene Symbol: | CTNNB1 |
| Organism: | Homo sapiens |
| Gene ID: | 1499 |
| UniProt ID: | P35222 |
Applications
WB, IHC-p, IF
Recommended Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300
Immunogen
Recombinant Protein
Purification/Format
Protein A purification
Background
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
- Catalog Number
RD85531A-20-RDB - Supplier
Reddot Biotech - Size
- Shipping
Blue Ice
Price
313,00 €
