KPNA2 Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human, Mouse |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1.08 mg/mL |
| Buffer: | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | IMA1, Importin alpha 1, Importin alpha 2, Importin alpha 2 subunit, Importin alpha P1, Importin subunit alpha-1, IPO A1, IPOA 1, IPOA1, Karyopherin alpha 2, Karyopherin alpha 2 RAG cohort 1, Karyopherin alpha 2 subunit, Karyopherin subunit alpha-2, KPNA2, KPNA2 protein, Pendulin, QIP 2, QIP2, RAG cohort 1, RAG cohort protein 1, RCH 1, RCH1, SRP 1, SRP1 alpha, SRP1, SRP1-alpha, SRP1alpha |
| Accn. No.: | BC005978 |
| UniProt ID: | P52292 |
Applications
IHC
Recommended Dilution
IHC 1:50-1:300
Immunogen
Fusion protein of human KPNA2
Purification/Format
Antigen affinity purification
Background
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.
- Catalog Number
E-AB-52984-20ul-ELS - Supplier
Elabscience - Size
- Shipping
Blue Ice
Price
202,00 €
