FAS Monoclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 10E5B10 |
| Host: | Mouse |
| Reactivity: | Human, Mouse |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 420 μg/mL |
| Buffer: | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | ALPS 1A, ALPS1A, APO 1, Apo 1 antigen, APO 1 cell surface antigen, Apo-1 antigen, APO1, Apo1 antigen, APO1 cell surface antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, APT 1, APT1, CD 95, CD 95 antigen, CD95, CD95 antigen, Delta Fas, Delta Fas/APO 1/CD95, Delta Fas/APO1/CD95, Fas (TNF receptor superfamily, member 6), FAS 1, FAS 827dupA, Fas AMA, Fas, FAS Antigen, Fas cell surface death receptor, FAS1, FASLG receptor, FASTM, sFAS, Surface antigen APO1, TNF receptor superfamily, member 6, TNFRSF 6, TNFRSF6, TNR6, Tumor necrosis factor receptor superfamily member 6 |
| UniProt ID: | P25445, P25446 |
Applications
IHC
Recommended Dilution
IHC 1:200-1:800
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse FAS
Purification/Format
Affinity purification
Background
FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.
Price
278,00 €
