E-Cadherin Monoclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | EC125D |
| Host: | Mouse |
| Reactivity: | Mouse, Rat |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1.6 mg/mL |
| Buffer: | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | Arc 1, CADH1, Cadherin 1, cadherin 1 type 1 E-cadherin, Cadherin1, CAM 120/80, CD 324, CD324, CD324 antigen, cdh1, CDHE, E-Cad/CTF3, E-cadherin, ECAD, Epithelial cadherin, epithelial calcium dependant adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin |
| UniProt ID: | P09803, Q9R0T4 |
Applications
IHC
Recommended Dilution
IHC 1:200-1:800
Immunogen
Recombinant protein corresponding to MouseE-cadherin
Purification/Format
Affinity purification
Background
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Price
278,00 €
