Anti-inflammatory agent 22

Anti-inflammatory agent 22 (compound 14a) is a potent orally active compound with anti-inflammatory properties. It effectively inhibits the production of TNF-α induced by LPS, exhibiting an IC50 value of 14.6 μM. Additionally, Anti-inflammatory agent 22 has demonstrated its ability to prevent adipogenesis and effectively suppress limb lymphedema volume in mice. This compound holds promise for the treatment of inflammation-related conditions, particularly lymphedematous tissue disorders [1].