AGRP Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human |
| Isotype: | IgG |
| Label: | Unconjugated |
| Additional Information | |
|---|---|
| Synonyms: | AGRT, ART, AGRP |
| UniProt ID: | O00253 |
Applications
ELISA, IHC
Recommended Dilution
Recommended dilution: IHC:1:20-1:200
Immunogen
Recombinant Human Agouti-related protein (83-132AA)
Purification/Format
Protein G purified
Background
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Price
472,00 €
