Anti-Caspase 3 Antibody

WB,ELISA

Recommended dilutions ELISA: 1:80,000 WB: 1/200 - 1/1000 Not yet tested in applications. Optimal dilutions/concentrations should be determined by the end user

peptide from the intermediate residues of human Caspase 3 protein

Peptide affinity purified

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.