ABC1183
| Specifications | |
|---|---|
| CAS Number: | 1042735-18-1 |
| Synonyms: | ABC-1183 |
| Formula: | C18H14N4OS |
| Molecular Weight: | 334,4 |
Description
ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression,and is orally active.
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