Laduviglusib trihydrochloride
| Specifications | |
|---|---|
| CAS Number: | 1782235-14-6 |
| Synonyms: | CHIR 99021 trihydrochloride |
| Formula: | C22H21Cl5N8 |
| Molecular Weight: | 574,72 |
Description
Laduviglusib trihydrochloride is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-3β with a Ki of 9.8 nM. Laduviglusib trihydrochloride is an activator of Wnt/β-catenin signaling. Laduviglusib trihydrochloride induces autophagy.
