Tazemetostat
| Specifications | |
|---|---|
| CAS Number: | 1403254-99-8 |
| Synonyms: | E-7438; Tazemetostat |
| Formula: | C34H44N4O4 |
| Molecular Weight: | 572.74 |
Description
Tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyltransferase EZH2, with potential antineoplastic activity. Upon oral administration, Tazemetostat selectively inhibits the activity of both wild-type and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27).
Product Citations
- Yu S, Zhou C, Cao S, et al. (2020) BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling Nature cell biology
- Cao Shangtao, Shengyong Yu, Dongwei Li, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang et al. (2018) Chromatin accessibility dynamics during chemical induction of pluripotency[J]. Cell Stem Cell 22(4): 529-542
- Catalog Number
T1788-1ml-TM - Supplier
TargetMol - Size
- Shipping
Blue Ice
Price
74,00 €
