Propargyl-PEG4-acid
Specifications | |
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CAS Number: | 1415800-32-6 |
Synonyms: | Propargyl-PEG4-acid |
Formula: | C12H20O6 |
Molecular Weight: | 260,28 |
Description
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1].
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