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Expires 30 June 2025
Rabbit anti-Mineralocorticoid receptor Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1.3 mg/mL |
| Buffer: | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
| Additional Information | |
|---|---|
| Synonyms: | Aldosterone receptor, MCR, MGC133092, Mineralocorticoid receptor, MLR, MR, NR3 C2, NR3C2, NR3C2 protein, Nuclear receptor subfamily 3 group C member 2 |
| UniProt ID: | P08235 |
Applications
WB
Recommended Dilution
WB 1:500-1:2000
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Mineralocorticoid receptor
Purification/Format
Affinity purification
Background
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Price
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