SMAD7 Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human, Mouse, Rat |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1mg/mL |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Applications
IHC, IF
Recommended Dilution
IHC 1:50-1:200, IF 1:50-1:200
Immunogen
A synthetic peptide of human SMAD7 (NP_005895.1).
Purification/Format
Affinity purification
Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Price
601,00 €
