Phospho-SMAD3 (Ser425) Monoclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | Clone:4C5 |
| Host: | Mouse |
| Reactivity: | Human, Mouse, Rat |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1 mg/mL |
| Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Additional Information | |
|---|---|
| Synonyms: | DKFZP586N0721, DKFZp686J10186, hMAD 3, hMAD-3, hSMAD3, HSPC193, HST17436, JV15 2, JV15-2, JV152, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, Mad homolog JV15 2, Mad protein homolog, MAD, mothers against decapentaplegic homolog 3, Mad3, MADH 3, MADH3, MGC60396, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMA and MAD related protein 3, SMAD 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, Smad3, SMAD3 |
| UniProt ID: | P84022 |
Applications
IHC-p
Recommended Dilution
IHC 1:50-300
Immunogen
Synthetic Peptide of Phospho-Smad3 (Ser425)
Purification/Format
Protein A purification
Background
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- Catalog Number
E-AB-51043-60ul-ELS - Supplier
Elabscience - Size
- Shipping
Blue Ice
Price
263,00 €
