DriverMap™ Human Cell Marker Panel

Product Description

The DriverMap Human Cell Marker Panel measures the expression level of 1,285 human protein-coding genes associated with immune and stromal cell types. The cell marker gene sets summarize and characterize gene signatures for 64 distinct cell types, spanning multiple adaptive and innate immunity cells, hematopoietic progenitors, epithelial cells, and extracellular matrix cells derived from thousands of published gene expression signatures. To generate the compendium of gene-specific signatures for human cell types, we used data from ENCODE, FANTOM, ImmGen, and the Human Primary Cells Atlas (HPCA). Also, we collected gene expression profiles from the Blueprint Project, from which we annotated 144 samples from 28 cell types, and the IRIS Project, from which we annotated 95 samples from 13 cell types. We collected and curated gene expression profiles from ~2,310 samples of pure cell types and annotated 64 distinct cell types and cell subsets.

The DriverMap Kit includes all the enzymes, reagents, and primers to prepare NGS-ready samples from total RNA, and includes software to demultiplex and align Illumina sequencing files (FASTQ) data and provide expression levels for each of the target genes.