HSP90AB1 Recombinant Monoclonal Antibody [7G7]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 7G7 |
| Host: | HEK293F Cell |
| Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Label: | Unconjugated |
| Additional Information | |
|---|---|
| Synonyms: | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84), HSP90AB1, HSP90B HSPC2 HSPCB |
| UniProt ID: | P08238 |
Applications
ELISA, WB, IHC, IF, FC
Recommended Dilution
Recommended dilution: WB:1:500-1:2000, IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200
Immunogen
A synthesized peptide derived from human HSP90AB1
Purification/Format
Affinity Chromatography
Background
HSP90 is a molecular chaperone that assists in the maturation, regulation, and maintenance of specific target proteins involved in cell cycle control and signal transduction. It undergoes a functional cycle driven by ATPase activity, leading to conformational changes in client proteins and their activation. Dynamic interaction with co-chaperones influences substrate recognition and chaperone function. Various client proteins are engaged through co-chaperones, forming functional chaperone complexes. After completion, properly folded client proteins and co-chaperones exit HSP90. Besides chaperoning, it also impacts transcription regulation at multiple levels. It counters STUB1-mediated TGF-beta signaling inhibition, aids cell differentiation, and plays a role in STAT1 activation. Additionally, it participates in leaderless cargo translocation to ERGIC.
Price
459,00 €
