STK3 Recombinant Monoclonal Antibody [3C3]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 3C3 |
| Host: | HEK293F Cell |
| Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Label: | Unconjugated |
| Additional Information | |
|---|---|
| Synonyms: | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N), Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)], STK3, KRS1 MST2 |
| UniProt ID: | Q13188 |
Applications
ELISA, WB
Recommended Dilution
Recommended dilution: WB:1:500-1:2000
Immunogen
A synthesized peptide derived from human STK3
Purification/Format
Affinity Chromatography
Background
Pro-apoptotic kinase activated by stress and caspase-cleavage, leading to nuclear entry and chromatin changes, including DNA fragmentation. Crucial part of the Hippo pathway, controlling organ size and tumor suppression by limiting proliferation and promoting apoptosis. The pathway involves a kinase cascade: STK3/MST2 and STK4/MST1 complexed with SAV1 activate LATS1/2 complexed with MOB1, ultimately inhibiting YAP1 and WWTR1/TAZ oncogenes. This inhibits their roles in gene regulation linked to proliferation, cell death, and migration. STK3/MST2 and STK4/MST1 also prevent hepatocyte proliferation, stem cell activation, and tumor growth. Phosphorylates NKX2-1, NEK2, and others for centrosome function, transcriptional activation, and RAF1 activity. Co-activates ESR1 with SAV1 and enhances STK38 with MOBKL1B.
Price
459,00 €
