CLDN18 Recombinant Monoclonal Antibody [25E3]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 25E3 |
| Host: | HEK293F Cell |
| Reactivity: | Human |
| Isotype: | hIgG1 |
| Label: | Unconjugated |
| Additional Information | |
|---|---|
| Synonyms: | Claudin-18, CLDN18 |
| UniProt ID: | P56856 |
Applications
ELISA, FC
Recommended Dilution
Recommended dilution: FC:1:50-1:200
Immunogen
Recombinant Human CLDN18 protein
Purification/Format
Affinity Chromatography
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Price
459,00 €
