MAPK14 Recombinant Monoclonal Antibody [6H8]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 6H8 |
| Host: | HEK293F Cell |
| Reactivity: | Human, Rat |
| Isotype: | Rabbit IgG |
| Label: | Unconjugated |
| Additional Information | |
|---|---|
| Synonyms: | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a), MAPK14, CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A |
| UniProt ID: | Q16539 |
Applications
ELISA, WB, IHC, IF
Recommended Dilution
Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200
Immunogen
A synthesized peptide derived from human p38 MAPK
Purification/Format
Affinity Chromatography
Background
The protein produced by this gene is part of the MAP kinase family. MAP kinases serve as hubs for various biochemical signals and are implicated in diverse cellular functions such as proliferation, differentiation, transcription regulation, and development. This kinase is activated by environmental stresses and proinflammatory cytokines. Activation involves phosphorylation by MAP kinase kinases (MKKs) or autophosphorylation triggered by interaction with MAP3K7IP1/TAB1 protein. Its substrates include transcription regulators ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, indicating its involvement in stress-related transcription, cell cycle regulation, and genotoxic stress response. This gene has four alternatively spliced transcript variants, each encoding distinct isoforms.
Price
459,00 €
