ITGAV Recombinant Monoclonal Antibody [5G3]

Specifications
Type:Primary Antibody
Clonality:Monoclonal
Clone Name:5G3
Host:HEK293F Cell
Reactivity:Human
Isotype:Rabbit IgG
Label:Unconjugated
Additional Information
Synonyms:Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain, Integrin alpha-V light chain], ITGAV, MSK8 VNRA VTNR
UniProt ID:P06756

Applications

ELISA, WB, IHC

Recommended Dilution

Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Immunogen

A synthesized peptide derived from human Integrin alpha V

Purification/Format

Affinity Chromatography

Background

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1.
  • Catalog Number
    A74459-050-EP
  • Supplier
    EpigenTek
  • Size
  • Shipping
    Blue Ice
Price
459,00 €
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