Phospho-PTPN11 (Y542) Recombinant Monoclonal Antibody [2E2]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 2E2 |
| Host: | HEK293F Cell |
| Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Label: | Unconjugated |
| Additional Information | |
|---|---|
| Synonyms: | Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2 |
| UniProt ID: | Q06124 |
Applications
ELISA, WB, IP
Recommended Dilution
Recommended dilution: WB:1:500-1:5000, IP:1:200-1:1000
Immunogen
A synthesized peptide derived from human Phospho-PTPN11 (Y542)
Purification/Format
Affinity Chromatography
Background
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73.
Price
459,00 €
