DKK3 Polyclonal Antibody, FITC Conjugated
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human |
| Isotype: | IgG |
| Label: | FITC |
| Additional Information | |
|---|---|
| Synonyms: | Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC, UNQ258/PRO295 |
| UniProt ID: | Q9UBP4 |
Applications
ELISA
Recommended Dilution
Recommended dilution: ELISA 1:100-1:500
Immunogen
Recombinant Human Dickkopf-related protein 3 protein (22-350AA)
Purification/Format
Protein G purified
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Price
591,00 €
