Anti-DOG1 / TMEM16A / ANO1 Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Host: | Mouse |
| Reactivity: | Human |
| Isotype: | Mouse IgG2b, kappa |
| Label: | Unconjugated |
| Concentration: | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
Applications
FACS, IF, IHC
Immunogen
A recombinant human protein corresponding to amino acids 2-11 of human DOG1 was used as the immunogen for this DOG1 antibody.
Background
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.
Price
512,00 €
