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Single Molecule Array (Simoa) Testing Service

Simoa® - Single Molecule Protein Detection

1000 Times More Sensitive than ELISA

Single molecule array (Simoa) testing is a powerful new technique that is orders of magnitude more sensitive than standard sandwich based immunoassay techniques. Traditional ELISA measurements are limited to pg/ml levels of detection. The RayBio Ultrasensitive Simoa Testing Services can achieve sensitivity as low as femtogram (fg/ml) levels, allowing the detection and quantification of biomarkers at concentrations previously difficult or impossible to measure.

  • Ideal for low abundance proteins, low volume samples 
  • Compatible with serum, plasma, CSF, other complex matrices
  • Multiplexing available for up to 4 analytes
  • Ship your samples, and we'll do the rest

Simoa requires a dedicated detector. For researchers who don't have accesss to such a device, we offer the Simoa Testing Service where samples can be shipped to us, and RayBiotech will perform the assay and create a data report. 

Simoa is based upon the isolation of individual immunocomplexes on paramagnetic beads using standard ELISA reagents. The main difference between Simoa and conventional immunoassays lies in the ability to trap single molecules in femtoliter-sized wells, allowing for a "digital" readout of each individual bead to determine if it is bound to the target analyte or not.

Traditional Vs Simoa