Recombinant Rat IL6RA/CD126 Protein (Fc tag, ECD)
| Specifications | |
|---|---|
| Molecular Weight: | 64.8 kDa |
| Tag: | C-Fc |
| Source: | HEK293 Cells |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg protein as determined by the LAL method. |
| Format: | Lyophilized from sterile PBS, pH 7.4 |
| Additional Information | |
|---|---|
| Synonyms: | Il6ra;IL-6R |
| Organism: | Rat |
| Accn. No.: | NP_058716.2 |
Sequence Information
Met1-Pro364
Background
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
- Catalog Number
PKSR030143-100ug-ELS - Supplier
Elabscience - Size
- Shipping
RT
Price
1.061,00 €
