Recombinant Human Prostaglandin-H2 D-isomerase (PTGDS)
| Specifications | |
|---|---|
| Molecular Weight: | 34.7kDa |
| Tag: | N-Terminal 6Xhis-Sumo-Tagged |
| Source: | E. coli |
| Purity: | >90% by SDS-PAGE |
| Endotoxin Level: | Not Tested |
| Additional Information | |
|---|---|
| Synonyms: | Beta-trace protein; Cerebrin-28Glutathione-independent PGD synthaseLipocalin-type prostaglandin-D synthaseProstaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2 |
| Organism: | Human (Homo sapiens) |
| Accn. No.: | P41222 |
Sequence Information
Full Length of Mature Protein 23~190aa
Background
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Price
2.480,00 €
