Recombinant Human Interleukin-18/IL-18 Protein
| Specifications | |
|---|---|
| Molecular Weight: | 18.2 kDa |
| Source: | E.coli |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg as determined by the LAL method. |
| Activity: | Measure by its ability to induce IFN gamma secretion in KG-1 cells. The ED50 for this effect is <5 ng/mL. |
| Format: | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Additional Information | |
|---|---|
| Synonyms: | Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma;GIF; IL-18; IL-1g; IL1F4; MGC12320; IL18 |
| Organism: | Human |
| Accn. No.: | Q14116 |
Sequence Information
Tyr37-Asp193
Background
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production; and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine; and thus negatively regulate its biological activity. After stimulation with IL-18; natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
Price
550,00 €
