Immortalized Human Endometrial Stromal Cells (HESC)
| Specifications | |
|---|---|
| Cell Category: | Immortalized Cell Lines |
| Organism: | Human |
| Tissue of Origin: | Endometria |
| Morphology: | Fibroblast-like |
| Culture Properties: | Adherent |
| Immortalization Method: | Serial passaging and transduction with retroviruses expressing hTERT from the supernatant of pA317-hTERT cell line |
| Marker: | IGFBP-1, PRL, TF, PAI-1 at decidualization endpoints |
| Donor Age: | Adult |
Propagation
Please contact us for propagation details.
Additional Information
Decidualization of the endometrium, mainly induced by progesterone, is a process of endometrial remodelling where the endometrial stromal cells differentiate into secretory decidual cells in preparation for pregnancy. Decidualized endometrial stromal cells are characterized by release of prolactin (PRL), insulin-like growth factor binding protein-1 (IGFBP-1), tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1), and expression of basal lamina components such as laminin, collagen IV, and fibronectin.
Immortalized Human Endometrial Stromal Cells (HESC) are unique in that 1) they display normal karyotype and 2) they respond to hormone stimulation and retain the morphological pattern and biochemical endpoints of decidualization after treatment of estradiol and medroxyprogesterone, making this cell line a valuable tool in endometrium homeostasis and female reproductive studies.
Note: The cells were collected from the endometrium of women who underwent hysterectomy, thus there is no specific age as the cells are pooled together to generate T0533.
Immortalized Human Endometrial Stromal Cells (HESC) are unique in that 1) they display normal karyotype and 2) they respond to hormone stimulation and retain the morphological pattern and biochemical endpoints of decidualization after treatment of estradiol and medroxyprogesterone, making this cell line a valuable tool in endometrium homeostasis and female reproductive studies.
Note: The cells were collected from the endometrium of women who underwent hysterectomy, thus there is no specific age as the cells are pooled together to generate T0533.
Commercial Price Disclaimer
Researchers at for-profit organizations and corporations, please contact us for pricing of this item.
Genetically Modified Organism (GVO)
See General Terms.
Product Citations
- Anthis, A. H. C., Kilchenmann, S., Murdeu, M., LeValley, P. J., Wolf, M., Meyer, C., Cipolato, O., Tibbitt, M. W., Rosendorf, J., Liska, V., Rduch, T., & Herrmann, I. K. (2024) Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli‐Responsive Hydrogels Advanced Materials
- Kendirci-Katirci, R., Sati, L., & Celik-Ozenci, C. (2024) Deciphering the role of rapamycin in modulating decidual senescence: implications for decidual remodeling and implantation failure Journal of Assisted Reproduction and Genetics
- Raja Xavier, J. P., Okumura, T., Apweiler, M., Chacko, N. A., Singh, Y., Brucker, S. Y., Takeda, S., Lang, F., & Salker, M. S. (2024) Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development Biological Research
- Raja Xavier, J. P., Rianna, C., Hellwich, E., Nikolou, I., Lankapalli, A. K., Brucker, S. Y., Singh, Y., Lang, F., Schäffer, T. E., & Salker, M. S. (2024) Excessive endometrial PlGF- Rac1 signalling underlies endometrial cell stiffness linked to pre-eclampsia Communications Biology
- Teworte, S., Behrens, M. C., Widhe, M., Gurzeler, L.-A., Hedhammar, M., & Luciani, P. (2024) A Fibronectin (FN)-Silk 3D Cell Culture Model as a Screening Tool for Repurposed Antifibrotic Drug Candidates for Endometriosis Small
- Catalog Number
T0533-GVO-ABM - Supplier
ABM - Size
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