Human Myostatin (Myostatin)
| Specifications | |
|---|---|
| Molecular Weight: | 12.4/24.8 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 50 ng/ml |
| Activity Assay: | MPC-11 cell cytotoxicity |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA) |
| Additional Information | |
|---|---|
| Synonyms: | GDF-8, MSTN |
| Organism: | Human |
| Accn. No.: | O14793 |
Sequence Information
DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
Background
Myostatin (GDF-8), a conserved member of the TGF-beta superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA, ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.
- Catalog Number
100-22AF-500UG-SHE - Supplier
Fujifilm Biosciences - Size
- Shipping
RT
Price
4.466,00 €
