Human Interleukin-13 (IL-13)
| Specifications | |
|---|---|
| Molecular Weight: | 12,6 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 5 ng/mL |
| Activity Assay: | TF-1 cell proliferation |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 10 mM Sodium Citrate, pH 3.0 |
| Additional Information | |
|---|---|
| Synonyms: | NC30 |
| Organism: | Human |
| Accn. No.: | P35225 |
Sequence Information
MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
Background
Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells. IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNFα), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression. IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells. The IL-13 receptor consists of the IL-4Ra and IL-13Ra1 subunits. IL-13 can also bind the IL-13Ra2 receptor with high affinity. IL-13 functions are mediated through the JAK/STAT signaling pathway. Human and mouse IL-13 are cross-reactive.
Price
7.079,00 €
