Human Gremlin / GREM1 Protein, Fc Tag
| Specifications | |
|---|---|
| Category: | Cytokines&Growth Factors |
| Molecular Weight: | 44.2 kDa |
| Tag: | C-Fc |
| Label / Conjugate: | N/A |
| Source: | Human Gremlin, Fc Tag (GR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504). |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | GREM1,CKTSF1B1,DAND2,DRM,PIG2 |
| Organism: | Human |
| Accn. No.: | NP_037504 |
Sequence Information
Lys 25 - Asp 184
Background
Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
Price
455,00 €
