Human Alpha-Synuclein Protein, His Tag
| Specifications | |
|---|---|
| Category: | Other Recombinant Proteins |
| Molecular Weight: | 16.3 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | Human Alpha-Synuclein, His Tag (ALN-H52H8) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | SNCA,NACP,PARK1,alpha-Synuclein |
| Organism: | Human |
| Accn. No.: | P37840-1 |
Sequence Information
Met 1 - Ala 140
Background
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Price
257,00 €
