Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag
| Specifications | |
|---|---|
| Category: | Immune Checkpoint Proteins |
| Molecular Weight: | 48.9 kDa |
| Tag: | C-Fc |
| Label / Conjugate: | Unconjugated |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Host: | HEK293 |
| Additional Information | |
|---|---|
| Synonyms: | CD244,2B4,SLAMF4,NKR2B4,NAIL,h2B4 |
| Organism: | Human |
| Accn. No.: | Q9BZW8-2 |
Sequence Information
Cys 22 - Arg 221
Background
Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
Price
401,00 €
