Biotinylated SARS-CoV-2 Spike Trimer Protein, His,Avitag (BQ.1.1/Omicron) (MALS verified)
| Specifications | |
|---|---|
| Category: | MABSol® Biotin Labeled Proteins |
| Molecular Weight: | 139.4 kDa |
| Tag: | C-10×His & C-Avi |
| Label / Conjugate: | Biotin-labeled |
| Source: | Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag (BQ.1.1/Omicron) (SPN-C82Ey) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1 (T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BQ.1.1). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively. |
| Purity: | 95% |
| Endotoxin Level: | N/A |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | Spike,S protein,Spike glycoprotein,S glycoprotein |
| Organism: | SARS-CoV-2 |
| Accn. No.: | QHD43416.1 |
Sequence Information
Val 16 - Pro 1213
Background
It's been reported that coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Price
779,00 €
