Biotinylated Human EGFR, His Tag & Avi Tag (Avitag™)
| Specifications | |
|---|---|
| Category: | MABSol® Biotin Labeled Proteins |
| Molecular Weight: | 72.3 kDa |
| Tag: | C-10×His & C-Avi |
| Label / Conjugate: | Biotin-labeled |
| Source: | Biotinylated Human EGF R, His,Avitag (EGR-H82E3) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645 (Accession # P00533-1). |
| Purity: | 90% |
| Endotoxin Level: | 0.1 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | EGFR,ERBB,ERBB1,HER1,PIG61,mENA |
| Organism: | Human |
| Accn. No.: | P00533-1 |
Sequence Information
Leu 25 - Ser 645
Background
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
Product Citations
- Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs A1, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV (2019) CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity Nat Biotechnol
- E Zhukovsky, O Leger, PE Gerard, A Pelegrin, C Larbouret (2019) Bispecific antibodies targeting egfr and her2 US20190153104A1
- Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ (2018) Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery Nat Biotechnol
Price
2.063,00 €
