Biotinylated Cynomolgus PSMA / FOLH1 Protein, His,Avitag™ (MALS verified)
| Specifications | |
|---|---|
| Category: | MABSol® Biotin Labeled Proteins |
| Molecular Weight: | 83.1 kDa |
| Tag: | N-10×His & N-Avi |
| Label / Conjugate: | Biotin-labeled |
| Source: | Biotinylated Cynomolgus PSMA Protein, His,Avitag (PSA-C82Q6) is expressed from human 293 cells (HEK293). It contains AA Lys 44 - Ala 750 (Accession # A0A2K5VNZ0). |
| Purity: | 95% |
| Endotoxin Level: | N/A |
| Format: | Powder |
| Additional Information | |
|---|---|
| Organism: | Cynomolgus |
| Accn. No.: | A0A2K5VNZ0 |
Sequence Information
Lys 44 - Ala 750
Background
Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily. FOLH1 / PSMA is stable at pH greater than 6.5. FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity. The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly – gamma - glutamates. FOLH1 / GCP-2 / PSMA has both folate hydrolase and N – acetylated – alpha – linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Price
505,00 €
