Anti-ds-DNA-A ELISA

Antibodies binding to DNA belong to the group of anti-nuclear antibodies (ANA) that have been observed in several autoimmune diseases. Antibodies reacting with native double-stranded (ds) DNA are regarded as being specific for systemic lupus erythematosus (SLE) and have been observed in approximately 50-80% of individuals with SLE. Research has shown approximately 30% SLE individuals develop IgA class anti-dsDNA antibodies. There have been suggestions that the presence of these IgA class anti-dsDNA antibodies may define a certain subset of SLE individuals. Indeed, studies have demonstrated the association of this subclass with certain parameters of the disease activity, such as elevated erythrocyte sedimentation rate, or the consumption of complement component C3.