HBL-1 Cells
| Specifications | |
|---|---|
| Cell Category: | Cancer Cells & Cell Lines |
| Organism: | Human |
| Morphology: | Polygonal |
| Culture Properties: | Suspension |
| Donor Age: | Donor Info Not Disclosed |
| Donor Gender: | Female |
| Donor Ethnicity: | Donor Info Not Disclosed |
| Pathology: | AIDS-related non-Hodgkin lymphoma |
Propagation
Additional Information
The HBL-1 cell line is derived from an AIDS-SNCCL (AIDS-associated small non-cleaved cell lymphoma) patient. After immunophenotypic and molecular genetic analysis, the HBL-1 was established from the original tumor clones. The HBL-1 cell line presents surface immunoglobulin and B-cell restricted markers as well as a phenotype consistent with SNCCL. This cell line also has a monoclonal infection of Epstein-Barr virus and displays clonal immunoglobulin gene rearrangement. Genetic lesions pertaining to the activation of the c-myc oncogene as well as inactivation of the p53 tumor suppressor gene is consistent with those found in AIDS-SNCCL. The HBL-1 cell line is considered useful as a model to study AIDS-associated non-Hodgkin lymphomagenesis (AIDS-NHL) and is also available as two other clones: HBL-2 (Cat. No. T8205 and HBL-3 (Cat. No. T8206).
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- Catalog Number
T8204-ABM - Supplier
ABM - Size
- Shipping
Dry Ice
- Price
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