Mouse Oral Carcinoma Cell Line (MTCQ1)

Propagation

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Additional Information

This murine tongue squamous cell carcinoma cell line (MTCQ1), established by 4NQO induction, expresses various epithelial cell markers and low levels of E-cadherin. MTCQ1 shows high Ki67 and PCNA expression, as well as alterations in its p53 expression. Western blot, qPCr and IHC were used to elucidate epithelium, EMT and stemness marker expression, as well as the murine origin of the cell line. MTCQ1 is capable of inducing primary tumors, regional and distal metastasis. As oral carcinoma (OSCC) is one of the leading cancers worldwide, established oral carcinoma cell lines serve as precilincal models for understanding OSCC and developing therapeutic strategies and interventions.