FDX1 Stable Knockout H9c2 Cell Line

PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. Dulbecco's Modified Eagle Medium (DMEM), High Glucose (TM500) + 10% FBS + 1% Penicillin/Streptomycin Solution (G255), 37.0°C, 5% CO₂.

This H9c2 cell line features a stable knockout of Ferredoxin 1 (FDX1) which is involved in iron-sulfur cluster assembly and electron transfer processes, which are critical for cellular metabolism and mitochondrial function. This cell line is particularly useful for research into cardiovascular diseases and mitochondrial function, as H9c2 cells are derived from rat cardiac muscle and are commonly used to study cardiac biology and metabolism. The knockout of the FDX1 gene allows researchers to investigate the specific role of this gene in cardiac cells, including its impact on mitochondrial efficiency, reactive oxygen species production, and overall cellular energy homeostasis. By studying the FDX1 Stable Knockout H9c2 Cell Line, scientists can gain insights into the fundamental processes affecting cardiac health, potentially leading to the development of targeted therapies for heart disease. This cell line serves as a valuable tool for both basic research and drug discovery processes focusing on cardiovascular and metabolic disorders.